Hydrifin borohydride products are used in the pharmaceutical and fine chemical industries where an effective reducing agent is needed. Because of the unique reduction properties, sodium borohydride is also used in various applications including agro chemicals, electronic industry and water treatment applications.
Sodium borohydride (NaBH4)
NaBH4 is a very effective and selective reducing agent. It is widely used in its dry form by the pharmaceutical and fine chemical industry in applications where an excellent hydrogenation and reduction is needed. The reductions can be carried out with a wide range of carbonyl substrates and the products are often building blocks especially for the synthesis of pharmaceutically active compounds. NaBH4 is also used to purify waste waters, product streams and organic chemicals by removing metal ions, carbonyl and peroxide impurities that cause undesirable odor, taste, color and instability to products.
NaBH4 is above all used for reducing aldehydes and ketones. Aldehydes can be reduced selectively in the presence of ketones. In alcoholic media or THF sodium borohydride reduces for example halides, anhydrides, quartenary pyridinium salts, double bonds conjugated to two electron-withdrawing groups and C-Hg bonds. It leaves under ambient conditions epoxides, esters and lactones, carboxylic acids, amides and most nitro compounds unreacted.
Sodium triacetoxyborohydride (NaBH(CH3COO)3)
Sodium triacetoxyborohydride (STAB) is a mild and selective reducing agent. It is able to replace toxic sodium cyanoborohydride under most conditions. It is selective in reducing aldehydes to alcohols in the presence of ketones. STAB is also stable in anhydrous acids, which enables reductive amination of aldehydes and ketones.
The advantage of STAB compared to sodium cyanoborohydride is evident. STAB, being non-toxic, is easier to handle and forms no toxic by-products, making the treatment of process waste after the reaction simple and less costly.